Detalhe da pesquisa
1.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
2.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
3.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
4.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
5.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
6.
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.
Chembiochem
; 19(5): 425-429, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226533
7.
Automated design of ligands to polypharmacological profiles.
Nature
; 492(7428): 215-20, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23235874
8.
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.
EMBO J
; 32(7): 1008-22, 2013 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23463102
9.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
10.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature
; 464(7289): 728-32, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360736
11.
The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.
Antimicrob Agents Chemother
; 57(10): 4699-706, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856774
12.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
J Med Chem
; 66(13): 8896-8916, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343180
13.
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
J Med Chem
; 66(15): 10413-10431, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506194
14.
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.
Eur J Med Chem
; 238: 114421, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594652
15.
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
J Med Chem
; 65(7): 5606-5624, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35303411
16.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220877
17.
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem
; 65(1): 409-423, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910486
18.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(9): 5905-5930, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904304
19.
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
ACS Omega
; 6(3): 2284-2311, 2021 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33521468
20.
Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease.
J Med Chem
; 63(6): 3066-3089, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32134269